CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response.

Leukozyten-Oberflächenantigen CD47 nach PDB 2JJS: Andere Namen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Leukocyte surface antigen CD47 Vorhandene Strukturdaten: PDB 2JJT, PDB 2VSC. Eigenschaften des menschlichen Proteins Masse/Länge Primärstruktur: 323 Aminosäuren, 35.214 Da: Bezeichner Externe IDs

Eigenschaften des menschlichen Proteins Masse/Länge Primärstruktur: 323 Aminosäuren, 35.214 Da: Bezeichner Externe IDs 2021-01-26 · CD47 deficiency may offer a potential therapeutic approach for preventing myocardial I/R injury. Evidence linking the overexpression of TSP1-CD47 signaling in diabetes to a number of parameters associated with endothelial dysfunction including impaired angiogenesis, cellular senescence and a heightened state of oxidative stress was found. The CD47-null mouse is lethally susceptible to bacterial infections that are of no consequence to wild-type mice because of a delay in neutrophil recruitment and a weakened integrin-dependent oxidative burst response. 33 In vitro data also support roles for CD47 in leukocyte adhesion to endothelium, 12 leukocyte transmigration, 34 and migration of dendritic cells. 35 CD47 is important in the 维基百科，自由的百科全书.

Cd47

Elle mat & vin. Språk: Svenska. Publiceringsår: 2006. No ratings. Ämnesord: Specialtidningar. Finns som: Vald medietyp: Tidskrift (2006).

I den här artikeln beskrivs rekommenderade steg för att analysera och felsöka saknade eller dubbla avtalade tider när du använder Microsoft Outlook och 3369, Kistagången 16, våningsplan 3, Electrum 1, KTH Kista.

Vi borde vara lyckliga. Undertitel: [Ångestpodden]. Av: Höckerstrand, Ida. Språk: Svenska. Publiceringsår: 2019. Klassifikation: Personlig utveckling och träning.

CD47–SIRPα interaction inhibits macrophage phagocytosis, allowing cancer cells to escape immune surveillance. Current focus in immunotherapy has been targeted toward inhibiting CD47–SIRPα interaction via anti-CD47 antibodies. This activates innate immunity, promoting cancer cell destruction by macrophages. It also activates CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.

TTI-622, an investigational CD47 inhibitor, showed preliminary signs of clinical activity with a manageable safety profile among patients with relapsed/refractory lymphoma, according to findings

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CD47 - Explore an overview of CD47, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. CD47 is cell surface protein that regulates the innate immune system by serving as an inhibitory signal for phagocytosis by macrophages, dendritic cells, and neutrophils. We originally identified increased expression of CD47 on AML stem cells, and subsequently identified high expression on many solid tumors including carcinomas, lymphomas, sarcomas, melanomas, and central nervous system tumors. Se hela listan på frontiersin.org 2 dagar sedan · Clinical trials are research studies that involve people.
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CD47-Directed TTI-622 Elicits Early Efficacy Signals in Relapsed/Refractory Lymphoma

Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. “There may be circumstances where host responses need boosting and CD47 represents a novel target for host-directed therapies in such cases,” the scientists write, mentioning SARS-CoV-2, HIV, HPV and Ebola virus among several possibilities. Article.

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CD47 and SIRPA are co-expressed in some cell types, and signaling functions involving lateral interactions have been proposed but not clearly established (Maile et al., 2003). CD47-induced SIRPA signaling in macrophages plays a role in limiting phagocytosis of RBCs, stem cells, and tumor cells.

CD47 is located on human chromosome 3q13. Immunogen CD47 molecule Application The SIRPα–CD47 axis was found to be highly species specific. Together, the results demonstrate that disruption of the SIRPα–CD47 immune checkpoint may augment NK cell antitumor responses and that elevated expression of CD47 may prevent NK cell–mediated killing of allogeneic and xenogeneic tissues. CD47 as a Macrophage Immune Checkpoint in Myeloid Malignancies. CD47 (also known as integrin associated protein) is a transmembrane protein that mainly functions as an anti-phagocytic or “do not eat me” signal, enabling CD47-expressing cells to evade phagocytic elimination by macrophages and other phagocytes. CD47 gene product.

CD47: role in the immune system and application to cancer therapy. Here, we review the role of CD47 in the maintenance of immune system homeostasis. We also depict three emerging CD47-targeting strategies for cancer therapy, including the use of mimicry …

It has an extracellular N -terminal IgV domain, five transmembrane domains, and a short C-terminal cytoplasmic tail. Showing subcellular location of CD47 (IAP, MER6, OA3). We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.

Size: 50µg think proteins! think G-Biosciences! www.GBiosciences.com NI-1701 / Anti-CD47/CD19.